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Medical news today Steroid treatment for rheumatoid arthritis has little effect on bone density reduction at low doses

Medical news today

Ajou University Professor Changhee Seo and Assistant Professor Jiwon Kim
Confirmed as the most appropriate dose of 2.5mg

medical news today

A study result showed that the use of low-dose steroids did not significantly affect the decrease in bone mineral density in patients with rheumatoid arthritis.

medical news today Professor Seo Chang-hee and Research Assistant Professor Kim Ji-won, Department of Rheumatology, Ajou University Hospital, took steroids for rheumatoid arthritis from 1999 to 2020. As a result of analyzing the clinical data of 833 patients who did not take steroids and 100 patients who did not take steroids, they found that 2.5 mg was the most appropriate dose that did not adversely affect bone density while maintaining the state of remission of rheumatoid arthritis. As a result of follow-up of the patient group and the control group for an average of 9 years and 3 months, there was no difference in the annual rate of change of bone density between the two groups and the rate of newly developed osteoporosis and fractures within the follow-up period. It means that steroid treatment did not significantly adversely affect bone density.medical news today , confirmed that ‘DAS28-ESR’, the disease activity of rheumatoid arthritis, is the only factor affecting the change in bone density. It was confirmed that bone loss can be prevented only by lowering the disease activity of rheumatoid arthritis through inflammatory treatment such as steroid treatment.medical news today

medical news today

Ajou University Hospital Rheumatology Department Professor Seo Chang-hee (left) and Kim Ji-won Research Assistant Professor

medical news today In the case of rheumatoid arthritis, the initial and symptoms worsen Steroids are administered to control inflammation, and this steroid inhibits bone formation and interferes with intestinal calcium absorption, increasing the risk of osteoporosis. medical news today Professor Seo Chang-hee said, “Rheumatoid arthritis patients have reduced activity levels due to pain, and inflammatory mediators secreted in the body adversely affect bone metabolism, leading to osteoporosis. Because the risk increases, it is essential to prevent osteoporosis and fractures through inflammation treatment, intake of calcium and vitamin D in daily life, and regular exercise,” he advised. medical news today The results of this study were published in the SCI international journal ‘Journal of Clinical Medicine’. medical news today

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