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Single-cell multimodal omics: the power of many

Advances in single-cell genomics technologies have enabled investigation of the gene regulation programs of multicellular organisms at unprecedented resolution and scale. Development of single-cell multimodal omics tools is another major step toward understanding the inner workings of biological systems.

References

  1. 1.

    Stuart, T. & Satija, R. Nat. Rev. Genet. 20, 257–272 (2019).

  2. 2.

    Dey, S. S., Kester, L., Spanjaard, B., Bienko, M. & van Oudenaarden, A. Nat. Biotechnol. 33, 285–289 (2015).

  3. 3.

    Macaulay, I. C. et al. Nat. Methods 12, 519–522 (2015).

  4. 4.

    Angermueller, C. et al. Nat. Methods 13, 229–232 (2016).

  5. 5.

    Hu, Y. et al. Genome Biol. 17, 88 (2016).

  6. 6.

    Hou, Y. et al. Cell Res. 26, 304–319 (2016).

  7. 7.

    Luo, C. et al. Preprint at bioRxiv https://doi.org/10.1101/434845 (2018).

  8. 8.

    Guo, F. et al. Cell Res. 27, 967–988 (2017).

  9. 9.

    Pott, S. Elife 6, e23203 (2017).

  10. 10.

    Clark, S. J. et al. Nat. Commun. 9, 781 (2018).

  11. 11.

    Wang, Y. et al. Preprint at bioRxiv https://doi.org/10.1101/803890 (2019).

  12. 12.

    Liu, L. et al. Nat. Commun. 10, 470 (2019).

  13. 13.

    Reyes, M., Billman, K., Hacohen, N. & Blainey, P. C. Advanced Biosystems 3, 1900065 (2019).

  14. 14.

    Satpathy, A. T. et al. Nat. Med. 24, 580–590 (2018).

  15. 15.

    Li, G. et al. Nat. Methods 16, 991–993 (2019).

  16. 16.

    Lee, D. S. et al. Nat. Methods 16, 999–1006 (2019).

  17. 17.

    Mateo, L. J. et al. Nature 568, 49–54 (2019).

  18. 18.

    Dixit, A. et al. Cell 167, 1853–1866.e1817 (2016).

  19. 19.

    Adamson, B. et al. Cell 167, 1867–1882.e1821 (2016).

  20. 20.

    Jaitin, D. A. et al. Cell 167, 1883–1896.e1815 (2016).

  21. 21.

    Rubin, A. J. et al. Cell 176, 361–376.e317 (2019).

  22. 22.

    Stoeckius, M. et al. Nat. Methods 14, 865–868 (2017).

  23. 23.

    Peterson, V. M. et al. Nat. Biotechnol. 35, 936–939 (2017).

  24. 24.

    Mimitou, E. P. et al. Nat. Methods 16, 409–412 (2019).

  25. 25.

    Cao, J. et al. Science 361, 1380–1385 (2018).

  26. 26.

    Zhu, C. et al. Nat. Struct. Mol. Biol. 26, 1063–1070 (2019).

  27. 27.

    Chen, S., Lake, B.B. & Zhang, K. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0290-0 (2019).

  28. 28.

    Kaya-Okur, H. S. et al. Nat. Commun. 10, 1930 (2019).

  29. 29.

    Rodriques, S. G. et al. Science 363, 1463–1467 (2019).

  30. 30.

    Chen, K. H., Boettiger, A. N., Moffitt, J. R., Wang, S. & Zhuang, X. Science 348, aaa6090 (2015).

  31. 31.

    Shah, S., Lubeck, E., Zhou, W. & Cai, L. Neuron 94, 752–758.e751 (2017).

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Author information

Affiliations

  1. Ludwig Institute for Cancer Research, La Jolla, CA, USA
    • Chenxu Zhu
    •  & Bing Ren
  2. Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA, USA
    • Sebastian Preissl
    •  & Bing Ren
  3. Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    • Sebastian Preissl
    •  & Bing Ren
  4. Institute of Genome Medicine, Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA
    • Bing Ren

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Correspondence to
Bing Ren.

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The authors declare no competing interests.

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